![]() We enjoy bike riding, kayaking, and exploring good food in the Quad Cities and surrounding areas. Today I live in Moline with my partner Shawn and our two dogs Oliver and Petey. This is part of serving your community that I learned from my grandpas. My experiences in Rockford and the Quad Cities were quite different - I was able to be out on TV! And in the Quad Cities, I took a more active role in our LGBTQ community - serving on the boards of Clock, Inc and The Project of the Quad Cities, initiatives that aim to connect vulnerable individuals to health services. from UC Davis, where my advisor was Greg Kuperberg. Recently, I was a visiting professor at UC Santa Barbara, and before that I earned my Ph.D. I was told that I couldn’t be gay and work there. Doob Research Assistant Professor in the University of Illinois Math Department and a member of the Illinois Quantum Information Science and Technology Center (IQUIST). I was called into my bosses’ office with a copy of my contract sitting on the desk and the “moral clause” highlighted. Get notified when PATH 290 has an open seat. College of Education: Visit User Services Learning Support. Unfortunately, he was right, and I experienced discrimination in that first job. , Amy MacNeill, Elizabeth Driskell, Eric Vimr, Lois Hoyer, Carol Maddox, Gee Lau, Mark Kuhlenschmidt, Uriel Kitron. You can also email us at, visit us online, or call us at 21. I remember my dad telling me that things would be “different” for me in Texas, and that it shouldn’t be that way. After graduating college, I moved south to Texas for my first television job. The combined results provide the first evidence for residues critical to acceptor binding and elongation in polysialyltransferase.I came out while attending Northern Illinois University and received tremendous support from my friends and family. Site-directed mutagenesis of the K92 polyST N terminus indicated that no single residue alteration was sufficient to affect specificity, consistent with the proposed function of this domain in orienting the acceptor. Krylov subspace methods for solving large sparse linear systems of. Eric de Sturler - University of Illinois, Urbana-Champaign, Computational Science and Engineering Program: Outline of Lecture. Iterative methods for linear, non-linear and eigenvalue problems. These results demonstrated that linkage specificity is dependent on residues located between positions 53 and 85 from the N terminus. University of Illinois, Urbana-Champaign. Exchanging the first 52 N-terminal amino acids of the K1 NeuS with the C terminus of the K92 homologue did not alter specificity of the resulting chimera, whereas exchanging the first 85 or reciprocally exchanging the first 100 residues did. To determine the molecular basis for linkage specificity, we created chimeras of the K1 and K92 polySTs by overlap extension PCR. The biochemical and immunochemical results demonstrated that linkage specificity is dictated solely by the source of the polymerase structural gene. coli K1 mutant with the polyST genes from groups B or C N. ![]() To better define the mechanism of capsule biosynthesis, we established the functional interchangeability of bacterial polySTs by complementation of a polymerase-deficient E. Despite the structural identity between bacterial and NCAM PSAs, the respective polysialyltransferases (polySTs) responsible for polymerizing sialyl residues from donor CMP-sialic acid are not homologous glycosyltransferases. PSA chains structurally identical to the bacterial alpha2,8-linked capsular polysaccharides are also synthesized by the mammalian central nervous system, where they regulate neuronal function in association with the neural cell adhesion molecule (NCAM). Polysialic acid (PSA) capsules are cell-associated homopolymers of alpha2,8-, alpha2,9-, or alternating alpha2,8/2,9-linked sialic acid residues that function as essential virulence factors in neuroinvasive diseases caused by certain strains of Escherichia coli and Neisseria meningitidis.
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